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Department of Medical Imaging and Radiological Science

 
 
:::

Shiaw-Pyng Wey

 

魏孝萍

Name:

Shiaw-Pyng Wey

Title:

Associate Professor

Education:

PhD, Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA

TEL & Mail:

03 - 2118800 # 5388

spwey@mail.cgu.edu.tw

Research Interest 

  • PET radiopharmaceuticals:
  1. Technical developments for improving cyclotron/target performance, module synthesis and quality testing
  2.  Novel 11C, 18F, and 68Ga-labeled tracer developments for neurology and oncology studies
  • SPECT radiopharmaceuticals: 99mTc and 123I-labeled tracer developments for imaging apoptosis, angiogenesis, and neural receptors/transporters
  • Technical developments and regulatory studies on Current Good Manufacture Practice (CGMP) of PET radiopharmaceutical production

Association :

01/1999至今

台灣核子醫學學會會員

06/1985至今

美國核子醫學學會會員

12/2006至今

台灣醫用迴旋加速器學會會員

Award/Licence :

08/1979

藥師證書

08/2003

放射性物質或可發生游離輻射設備輻射安全證書

02/2006

放射性物質生產設施運轉人員證書

Instruction Courses :

  1. Radiochemistry

  2. Radiation Safety

  3. Radiopharmaceutical

Journal Papers :

1.      Kao CH, Wang SJ, Wey SP, Shen LH, Ting G, Yeh SH. Using technetium-99m (V) dimercaptosuccinic acid to detect malignancies from single solid masses in the lungs. Eur J Nucl Med 1992;19:890-893. (SCI)

2.      Yang CC, Wu CC, Jong SB, Shen LH, Wey SP, Ting G. Intravenous dipyridamole technetium-99m MMI myocardial perfusion scintigraphy for detection of coronary artery disease. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih 1992; 8:59-74. (SCI)

3.      Kao CH, Wang SJ, Wey SP, Shen LH, Ting G, Yeh SH. The detection of nasopharynx carcinoma in technetium-99m (V) dimercaptosuccinic acid SPECT imaging. Clin Nucl Med 1993;18:321-323. (SCI)

4.      Wey SP, Ibrahim AM, Green MA. Synthesis and crystal structure of a copper(II) complex with a tetradentate dithiadioxime ligand. Polyhedron 1995;14:1097-1100. (SCI)

5.      Wey SP, Hsiao YM, Mathias CJ, Green MA. Synthesis and biodistribution of indium(III) complexes with hexadentate bis(salicylaldimine) ligands. J Labelled Compds Radiopharm 1995;37:770-772. (SCI)

6.      王信二,季匡華,顏上惠,陳富都,周衛樂,黃廣良,魏孝萍,丁幹。肝癌治療核醫藥物[125I/131I]Iododeoxyuridine之合成與配方研究。放射治療與腫瘤學雜誌 1998;5:285-291(SCI)

7.      王信二,張智偉,林漢民,劉仁賢,林欣榮,陳富都,魏孝萍,丁幹。Radiosynthesis of 6-[18F]fluoro-L-DOPA for dopaminergic function imaging with PET。核子醫學雜誌 1999;12:1-6(SCI)

8.      蔡世傳,林萬鈺,廖美秀,王世楨,魏孝萍,沈立漢,丁幹。核研所鎝-99m-MAG3腎功能診斷核醫藥物之臨床評估。核子醫學雜誌 1999;12:7-11(SCI)

9.      王世楨,林萬鈺,林武智,沈立漢,黃亨通,丁幹。鉈-201/-99m刪除性掃描於不正常副甲狀腺之診斷:與其他造影方法之比較。核子醫學雜誌 1999;12:23-28(SCI)

10.  黃文盛,馬國欣,林欣榮,魏孝萍,林正憲,丁幹,劉仁賢,劉江川。Imaging of parkinsonian monkey using 99mTc-TRODAT-1: A preliminary report。核子醫學雜誌 1999;12:69-75(SCI)

11.  王世楨,蔡世傳,林萬鈺,高嘉鴻,吳美智,魏孝萍,沈立漢,蔡瑞燦,丁幹。鎝-99m-HMPAO添加穩定劑之研究。核子醫學雜誌 1999;12:77-83(SCI)

12.  張國平,魏孝萍,陳清奎,沈立漢。微量放射性不純核種對同位素校正儀量測鉈-201放射活度之影響與修正。核子醫學雜誌 1999;12:143-150(SCI)

13.  Kao CH, Huang WT, Wey SP, Changlai SP, Liao KK, Tsai CS. A trial study of leukocyte labeling with stabilized Tc-99m-D,L-HMPAO by methylene blue and sodium phosphate buffer. Appl Radiat Isot 1999;50:513-519. (SCI)

14.  Wang SJ, Lin WY, Wey SP, Shen LH, Ting G. Pentavalent Tc-99m dimercaptosuccinic acid imaging of hepatocellular carcinoma. Neoplasma 1999;46:246-248. (SCI)

15.  Yen TC, Lu CS, Tzen KY, Wey SP, Chou YH, Weng YH, Kao PF, Ting G. Decreased dopamine transporter binding in Machado-Joseph disease. J Nucl Med 2000;41:994-998. (SCI)

16.  Sharma V, Beatty A, Wey SP, Dahlheimer J, Pica CM, Crankshaw CL, Bass L, Green MA, Welch MJ, Piwnica-Worms D. Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo. Chem Biol 2000;7:335-343. (SCI)

17.  Kung HF, Wey SPKung MP. SPECT imaging agents for dopamine and serotonin transporters in the brain. Ann Nucl Med Sci 2000;13:165-174. (SCI)

18.  蔡世傳,孫盛生,魏孝萍,沈立漢,丁幹。碘-123--CIT製備及在巴金森氏症診斷之動物研究。核子醫學雜誌 2000;13:217-223(SCI)

19.  Kao P-F, Tzen K-Y, Yen T-C, Lu C-S, Weng Y-H, Wey S-P, G Ting. The optimal imaging time for [99mTc] TRODAT-1/SPET in normal subjects and patients with Parkinson's disease. Nucl Med Commun 2001;22:151-154. (SCI)

20.  Tzen K-Y, Lu C-S, Yen T-C, Wey S-P, Ting G. Differential diagnosis of Parkinson’s disease and vascular parkinsonism by 99mTc TRODAT-1. J Nucl Med 2001;42:408-413. (SCI)

21.  Huang Wen-Sheng, Lin Shinn-Zong, Liu Jiann-Chyun, Wey Shiaw-Pyng, Ting Gann, Liu Ren-Shyan. Evaluation of early-stage Parkinson’s disease with 99mTc-TRODAT-1 imaging. J Nucl Med 2001;42:1303-1308. (SCI)

22.  Choi SR, Yang B, Plossl K, Chumpradit S, Wey SP, Acton PD, Wheeler K, Mach RH, Kung HF. Development of Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent. Nucl Med Biol 2001;28:657-666. (SCI)

23.  Chen YK, Liu RS, Huang WS, Wey SP, Ting G, Liu JC, Shen YY, Wang FJ. The role of dopamine transporter imaging agent [99mTc]TRODAT-1 in hemi-parkinsonism rat brain. Nucl Med Biol 2001;28:923-928. (SCI)

24.  廖美秀,張國平,魏孝萍,沈立漢。以雙片薄層色層分析法檢測多巴胺轉運體造影劑鎝-99m-TRODAT-1之放射化學純度。核子醫學雜誌 2001;14:223-230(SCI)

25.  Hwang Wen-Juh, Yao Wei-Jen, Wey Shiaw-Pyng, Shen Lie-Hang, Ting Gann. Downregulation of striatal dopamine D2 receptors in advanced Parkinson’s disease contributes to the development of motor fluctuation. Eur Neurol 2002;47:113-117. (SCI)

26.  Yen Tzu-Chen, Tzen Kai-Yuan, Chen Min-Chi, Wu Chou Yah-Huei, Chen Rou-Shayn, Chen Chi-Jen, Wey Shiaw-Pyng, Ting Gann, Lu Chin-Song. Dopamine transporter concentration is reduced in asymptomatic Machado-Joseph disease gene carriers. J Nucl Med 2002;43:153-159. (SCI)

27.  Huang WS, Ma KH, Chen CH, Wey SP, Chou YH, Chen CY, Ting G, Liu JC. 123I-ADAM SPECT in healthy nonhuman primates: A preliminary report. Ann Nucl Med Sci 2002;15:27-32. (SCI)

28.  Hung GU, Weng YC, Lin WY, Wang SJ, Hsia CC, Wey SP, Wang HE, Lin CH, Shen LH, Ting G. Preliminary study of 99mTc-HL91 on a tumor mouse model. Ann Nucl Med Sci 2002;15:85-91. (SCI)

29.  Ma KH, Huang WS, Chen CH, Lin SZ, Wey SP, Ting G, Wang SD, Liu HW, Liu JC. Dual SPECT of dopamine system using [99mTc]TRODAT-1 and [123I]IBZM in normal and 6-OHDA-lesioned formosan rock monkeys. Nucl Med Biol 2002;29:561-567. (SCI)

30.  Hwang JJ, Liao MH, Yen TC, Wey SP, Lin KJ, Pan WHT, Chen JC, G Ting. Biodistribution study of [99mTc]TRODAT-1 alone or combined with other dopaminergic drugs in mice with macroautography. Appl Radiat Isot 2002;57:35-42. (SCI)

31.  Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G, Hwang JJ. Biodistribution study of [123I] ADAM in mice: correlation with whole body autoradiography. Nucl Med Biol 2002;29:643-650. (SCI)

32.  Hsia CC, Wang HE, Wey SP, Liu RS, Shen LH. Biodistribution study of 99mTc-HL91 in sarcoma-bearing mice. Ann Nucl Med Sci 2003;16:131-136. (SCI)

33.  Huang WS, Lee MS, Lin JC, Chen CY, Yang YW, Lin SZ, Wey SP. Usefulness of brain 99mTc-TRODAT-1 SPET for the evaluation of Parkinson's disease. Eur J Nucl Med Mol Imaging 2004;31(2):155-161. (SCI)

34.  Hwang WJ, Yao WJ, Wey SP, Ting G. Clinical and [99mTc]TRODAT-1/[123I]IBZM SPECT imaging findings in dopa-responsive dystonia. Eur Neurol 2004;51:26-29. (SCI)

35.  Lu CS, Weng YH, Chen MC, Chen RS, Tzen KY, Wey SP, Ting G, Chang HC, Yen TC. 99mTc-TRODAT-1 Imaging of Multiple System Atrophy. J Nucl Med 2004;45:49-55. (SCI)

36.  Hwang WJ, Yao WJ, Wey SP, Ting G. Reproducibility of 99mTc-TRODAT-1 SPECT Measurement of Dopamine Transporters in Parkinson's Disease. J Nucl Med. 2004;45:207-213. (SCI)

37.  Weng YH, Yen TC, Chen MC, Kao PF, Tzen KY, Chen RS, Wey SP, Ting G, Lu CS. Sensitivity and Specificity of 99mTc-TRODAT-1 SPECT Imaging in Differentiating Patients with Idiopathic Parkinson's Disease from Healthy Subjects. J Nucl Med 2004;45:393-401. (SCI)

38.  Lin KJ, Yen TC, Wey SP, Hwang JJ, Ye XX, Tzen KY, Fu YK, Chen JC. Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. J Nucl Med 2004;45:673-681. (SCI)

39.  Lai SC, Weng YH, Yen TC, Tsai CC, Chang HC, Wey SP, Ting G, Lu CS. Imaging early-stage corticobasal degeneration with [99mTc]TRODAT-1 SPET. Nucl Med Commun 2004;25(4):339-345. (SCI)

40.  Huang WS, Ma KH, Cheng CY, Chen CY, Fu YK, Chou YH, Wey SP, Liu JC. Imaging serotonin transporters with 123I-ADAM brain SPECT in healthy non-human primates. Nucl Med Commun 2004;25:515-519. (SCI)

41.  Ye XX, Chen JC, Liu RS, Wey SP, Lee JS, Chen CC, Fu YK, Ting G, Hwang JJ. Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nucl Med Biol 2004;31(5):557-562. (SCI)

42.  Ye XX, Hwang JJ, Hsieh JF, Chen JC, Chou YT, Tu KY, Wey SP, Ting G. In vivo quantification by SPECT of [123I] ADAM bound to serotonin transporters in the brains of rabbits. Nucl Med Biol 2004;31(8):995-1003. (SCI)

43.  Wang SJ, Lo JM, Shen LH, *Wey SP. Tumor uptake of 99mTc-HL91 and 99mTc-PnAO-nitroimidazole in an animal model of non-small cell lung cancer. Ann Nucl Med Sci 2004;17(3):139-146. (SCI)

44.  Lin KJ, Liu CY, Wey SP, Hsiao IT, Wu J, Fu YK, Yen TC. Brain SPECT imaging and whole-body biodistribution with [123I]ADAM - a serotonin transporter radiotracer in healthy human subjects. Nucl Med Biol 2006 Feb;33(2):193-202. (SCI)

45.  Liao MH, Jan TR, *Wey SP, Chiang CC, Chi CW, Fu YK, Shen LH. A feasible method to prepare 123I-annexin V for imaging apoptosis. Ann Nucl Med Sci 2006 Dec;19(4):231-238. (SCI)

46.  Wang CC, Liu TY, Wey SP, Wang FI, Jan TR. Areca nut extract suppresses T-cell activation and interferon-gamma production via the induction of oxidative stress. Food Chem Toxicol 2007 Aug;45(8):1410-1418. (SCI)

47.  Jan TR, Wey SP, Kuan CC, Liao MH, Wu HY. Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice. Planta Med 2007 May;73(5):421-426. (SCI)

48.  Weng YH, Wu Chou YH, Wu WS, Lin KJ, Chang HC, Yen TC, Chen RS, Wey SP, Lu CS. PINK1 mutation in Taiwanese early-onset parkinsonism: clinical, genetic, and dopamine transporter studies. J Neurol 2007 Oct;254(10):1347-1355. (SCI)

49.  Kung HF, Kung MP, Wey SP, Lin KJ, Yen TC. Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT. Nucl Med Biol 2007 Oct;34(7):787-789. (SCI)

50.  Lee CY, Wey SPLiao MH, Hsu WL, Wu HY, Jan TR. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cellsInt Immunopharmacol 2008 May;8(5):732-740. (SCI)

51.  Wey SP, Wu HY, Chang FC, Jan TR. Methamphetamine and diazepam suppress antigen-specific cytokine expression and antibody production in ovalbumin-sensitized BALB/c mice. Toxicol Lett 2008 Oct;181(3):157-162. (SCI)

52.  Sonaje K, Lin YH, Juang JH, Wey SP, Chen CT, Sung HW. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 2009 Apr;30(12):2329-2339. (SCI)

53.  Hsiao YM, Mathias CJ, Wey SP, Fanwick PE, Green MA. Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: potential agents for PET myocardial imaging with 68Ga. Nucl Med Biol 2009 Jan;36(1):39-45. (SCI)

54.  Wey SPWeng CC, Lin KJ, Yao CH, Yen TC, Kung HK, Skovronsky D, Kung MP. Validation of an 18F-labeled biphenylalkyne as a PET imaging agent for b-amyloid plaques. Nucl Med Biol 2009 May;36(4):411-417. (SCI)

55.  Lin KJ, Liu HL, Hsu PH, Chung YH, Huang WC, Chen JC, Wey SP, Yen TC, Hsiao IT. Quantitative micro-SPECT/CT for detecting focused ultrasound-induced blood-brain barrier opening in the rat. Nucl Med Biol 2009 Oct;36(7):853-861. (SCI)

56.  Chen MC, Wong HS, Lin KJ, Chen HL, Wey SP, Sonaje K, Lin YH, Chu CY, Sung HW. The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials 2009 Dec;30(34):6629-6637. (SCI)

57.  Kao PF, Wey SP, Yang AS. Simultaneous 99mTc and 123I dual-isotope brain striatal phantom single photon emission computed tomography: validation of 99mTc-TRODAT-1 and 123I-IBZM simultaneous dopamine system brain imaging. Kaohsiung J Med Sci 2009 Nov;25(11):601-607. (SCI)

58.  Lee PW, Hsu SH, Wang JJ, Tsai JS, Lin KJ, Wey SP, Chen FR, Lai CH, Yen TC, Sung HW. The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core-shell nanoparticles. Biomaterials 2010 Feb;31(6):1316-1324. (SCI)

59.  Lee ML, Kung MP, Lin KJ, Liao MH, Lin CH, Shen LH, *Wey SPCan iodo-GTS-21 be a model to develop new tracer for imaging central nicotinic receptors? Ann Nucl Med Sci 2010 Mar;23(1):19-28. (SCI)

60.  Sonaje K, Chen YJ, Chen HL, Wey SP, Juang JH, Nguyen HN, Hsu CW, Lin KJ, Sung HW. Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials 2010 Apr;31(12):3384-3394. (SCI)

61.  Tsao HH, Lin KJ, Juang JH, Skovronsky DM, Yen TC, *Wey SP, *Kung MP. Binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine (AV-133) to the vesicular monoamine transporter type 2 in rats. Nucl Med Biol 2010 May;37(4):413-419. (SCI)

62.  Lin KJ, Hsu WC, Hsiao IT, Wey SP, Jin LW, Skovronsky D, Wai YY, Chang HP, Lo CW, Yao CH, Yen TC, Kung MP. Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent — a pilot study. Nucl Med Biol 2010 May;37(4):497-508. (SCI)

63.  Yen TC, Wey SP, Liao CH, Yeh CH, Shen DW, Achilefu S, *Wun TC. Measurement of the binding parameters of annexin derivatives-erythrocyte membrane interactions. Anal Biochem 2010 November;406(1):70-79. (SCI)

64.  Sonaje K, Lin KJ, Wey SP, Lin CK, Yeh TH, Nguyen HN, Hsu CW, Yen TC, Juang JH, Sung HW. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection. Biomaterials 2010 Sep;31(26):6849-6858. (SCI)

65.  Yao CH, Lin KJ, Weng CC, Hsiai IT, Ting YS, Yen TC, Jan TR, Skovronsky D, Kung MP, *Wey SP. GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging beta-amyloid plaques in human brain. Appl Radiat Isot 2010 Dec;68(12):2293-2297. (SCI)

66.  Wang CC, Hung-Li Lin HL, Wey SP, *Jan TR. Areca nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice. Immunopharmacol Immunotoxicol 2011 Jun;33(2):315-322. (SCI)

67.  Lin KJ, Weng YH, Wey SP, Hsiao IT, Lu CS, Skovronsky D, Chang HP, Kung MP, *Yen TC. Whole-body biodistribution and radiation dosimetry of 18F-FP-(+)-DTBZ (18F-AV-133): a novel vesicular monoamine transporter 2 imaging agent. J Nucl Med 2010 Sep;51(9):1480-1485. (SCI)

68.  Liao MH, Wey SP, Jan ML, Chiang CC, Liao TZ, Chi CW, Shen LH, *Jan TR. Monitoring of 2-deoxy-2-[18F]fluoro-D-glucose uptake in tumor-bearing mice using high-sensitivity projection imaging: compared with PET imaging. Nucl Med Commun 2010 Dec;31(12):1040-1044. (SCI)

69.  Liu DZ, Hu CM, Huang CH, Wey SP, *Jan TR. Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity. Acta Pharmacol Sin 2010 Dec;31(12):1611-1617. (SCI)

70.  Lu PL, Chen YC, Ou TW, Chen HH, Tsai HC, Wen CJ, *Lo CL, Wey SP, Lin KJ, *Yen TC, *Hsiue GH. Multifunctional hollow nanoparticles based on graft-diblock copolymers for doxorubicin delivery. Biomaterials 2011 Mar;32(8):2213-2221. (SCI)

71.  Nguyen HN, Wey SP, Juang JH, Sonaje K, Ho YC, Chuang EY, Hsu CW, Yen TC, *Lin KJ, *Sung HW. The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo. Biomaterials 2011 Apr;32(10):2673-2682. (SCI)

72.  Wang TC, Hsiao IT, Cheng YK, Wey SP, Yen TC, Lin KJ. Noninvasive monitoring of tumor growth in a rat glioma model: comparison between neurological assessment and animal imaging. J Neurooncol 2011 Sep;104(3):669-678. (SCI)

73.  Liao MH, Jan TR, Chiang CC, Yen KC, Liao TZ, Chen MW, Chi CW, *Wun TC, Yen TC, *Wey SP. Investigation of a potential scintigraphic tracer for imaging apoptosis: radioiodinated annexin V-Kunitz protease inhibitor fusion protein. J Biomed Biotechnol 2011;2011:675701. Epub 2011 Apr 27. (SCI)

74.  Lin KJ, Lin WY, Hsieh CJ, Weng YH, Wey SP, Lu CS, Skovronsky D, Yen TC, Chang CJ, Kung MP, Hsiao IT. Optimal scanning time window for 18F-FP-(+)-DTBZ (18F-AV-133) summed uptake measurements. Nucl Med Biol 2011 Nov;38(8):1149-1155. (SCI)

75.  Sonaje K, Lin KJ, Tseng MT, Wey SP, Su FY, Chuang EY, Hsu CW, Chen CT, Sung HW. Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins. Biomaterials 2011 Nov;32(33):8712-8721. (SCI)

76.  Tsao HH, Skovronsky DM, Lin KJ, Yen TC, Wey SP, Kung MP. Sigma receptor binding of tetrabenazine series tracers targeting VMAT2 in rat pancreas. Nucl Med Biol 2011 Oct;38(7):1029-1034. (SCI)

77.  Su FY, Lin KJ, Sonaje K, Wey SP, Yen TC, Ho YC, Panda N, Chuang EY, Maiti B, Sung HW. Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery. Biomaterials. 2012 Mar;33(9):2801-2811. (SCI)

78.  Hsiao IT, Huang CC, Hsieh CJ, Hsu WC, Wey SP, Yen TC, Kung MP, Lin KJ. Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies: reply to Ballinger. Eur J Nucl Med Mol Imaging 2012 Apr;39(4):613-620. (SCI)

79.  Huang KL, Lin KJ, Ho MY, Chang YJ, Chang CH, Wey SP, Hsieh CJ, Yen TC, Hsiao IT, Lee TH. Amyloid deposition after cerebral hypoperfusion: Evidenced on [18F]AV-45 positron emission tomography. J Neurol Sci 2012 Aug;319(1-2):124-129. (SCI)

80.  Chao KT, Tsao HH, Weng YH, Hsiao IT, Hsieh CJ, Wey SP, Yen TC, Kung MP, Lin KJ. Quantitative analysis of binding sites for 9-fluoropropyl-(+)-dihydrotetrabenazine ([18F]AV-133) in a MPTP-lesioned PD mouse model. Synapse 2012 Sep;66(9):823-831. (SCI)

81.  Kung MP, Weng CC, Lin KJ, Hsiao IT, Yen TC, Wey SP. Amyloid plaque imaging from IMPY/SPECT to AV-45/PET. Chang Gung Med J 2012 May-Jun; 35(3):211-218. (SCI)

82.  Yang HW, Hua MY, Lin KJ, Wey SP, Tsai RY, Wu SY, Lu YC, Liu HL, Wu T, Ma YH. Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis. Int J Nanomed 2012 Sep;7:5159-5173. (SCI)

83.  Hsiao IT, Huang CC, Hsieh CJ, Wey SP, Kung MP, Yen TC, Lin KJ. Perfusion-like template and standardized normalization-based brain image analysis using 18F-florbetapir (AV-45/Amyvid) PET. Eur J Nucl Med Mol Imaging 2013 Jun;40(6):908-920. (SCI)

84.  Huang KL, Lin KJ, Hsiao IT, Kuo HC, Hsu WC, Chuang WL, Kung MP, Wey SP, Hsieh CJ, Wai YY, Yen TC, Huang CC. Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in chinese population. PLoS One 2013;8(3):e58974.  [Epub 2013 Mar 14](SCI)

85.  Chu PC, Chai WY, Hsieh HY, Wang JJ, Wey SP, Huang CY, Wei KC, Liu HL. Pharmacodynamic analysis of magnetic resonance imaging-monitored focused ultrasound-induced blood-brain barrier opening for drug delivery to brain tumors. Biomed Res Int 2013;2013:627496. (SCI)

86.  Chuang EY, Lin KJ, Su FY, Mi FL, Maiti B, Chen CT, Wey SP, Yen TC, Juang JH, Sung HW. Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats. J Control Release 2013 Dec 10;172(2):513-522. (SCI)

87.  Yang HW, Hua MY, Hwang TL, Lin KJ, Huang CY, Tsai RY, Ma CC, Hsu PH, Wey SP, Hsu PW, Chen PY, Huang YC, Lu YJ, Yen TC, Feng LY, Lin CW, Liu HL, Wei KC. Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide. Adv Mater 2013 Jul 12;25(26):3605-3611. (SCI)

88.  Yang HW, Lu YJ, Lin KJ, Hsu SC, Huang CY, She SH, Liu HL, Lin CW, Xiao MC, Wey SP, Chen PY, Yen TC, Wei KC, Ma CC. EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy. Biomaterials 2013; Sep;34(29):7204-7214. (SCI)

89.  Lo CL, Chou MH, Lu PL, Lo IW, Chiang YT, Hung SY, Yang CY, Lin SY, Wey SP, Lo JM, Hsiue GH. The effect of PEG-5K grafting level and particle size on tumor accumulation and cellular uptake. Int J Pharm 2013 Nov 18;456(2):424-431. (SCI)

90.  Lin KJ, Weng YH, Hsieh CJ, Lin WY, Wey SP, Kung MP, Yen TC, Lu CS, Hsiao IT. Brain Imaging of Vesicular Monoamine Transporter Type 2 in Healthy Aging Subjects by 18F-FP-(+)-DTBZ PET. PLoS One 2013 Sep 30;8(9):e75952. (SCI)

91.  Lin SC, Lin KJ, Hsiao IT, Hsieh CJ, Lin WY, Lu CS, Wey SP, Yen TC, Kung MP, Weng YH. In vivo detection of monoaminergic degeneration in early Parkinson disease by 18F-9-fluoropropyl-(+)-dihydrotetrabenzazine PET. J Nucl Med 2014 Jan;55(1):73-79. (SCI)

92.  Su FY, Chuang EY, Lin PY, Chou YC, Chen CT, Mi FL, Wey SP, Yen TC, Lin KJ, Sung HW. Treatment of chemotherapy-induced neutropenia in a rat model by using multiple daily doses of oral administration of G-CSF-containing nanoparticles. Biomaterials 2014 Apr;35(11):3641-3649. (SCI)

93.  Hsiao IT, Weng YH, Lin WY, Hsieh CJ, Wey SP, Yen TC, Kung MP, Lu CS, Lin KJ. Comparison of 99mTc-TRODAT-1 SPECT and 18F-AV-133 PET imaging in healthy controls and Parkinson's disease patients. Nucl Med Biol 2014 Apr;41(4):322-329. (SCI)

94.  Wang PH, Yu CP, Lee TH, Lin CW, Ismail W, Wey SP, Kuo AT, Chiang YR. Anoxic androgen degradation by the denitrifying sterolibacterium denitrificans via the 2,3-seco-pathway. Appl Environ Microbiol 2014 Jun;80(11):3442-3452. (SCI)

95.  Chen KJ, Chaung EY, Wey SP, Lin KJ, Cheng F, Lin CC, Liu HL, Tseng HW, Liu CP, Wei MC, Liu CM, Sung HW. Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy. ACS Nano 2014 May 27;8(5):5105-5115. (SCI)

96.  Hsiao IT, Weng YH, Hsieh CJ, Lin WY, Wey SP, Kung MP, Yen TC, Lu CS, Lin KJ. Correlation of Parkinson disease severity and 18F-DTBZ positron emission tomography. JAMA Neurol 2014 Jun 1;71(6):758-766. (SCI)

97.  Weng CC, Chen ZA, Chao KT, Ee TW, Lin KJ, Chan MH, Hsiao IT, Yen TC, Kung MP, *Hsu CH, *Wey SP. Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson's disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging. PLoS One 2017 Mar 3;12(3):e0173503. (SCI)

98.  Hsiao IT, Lin KJ, Huang KL, Huang CC, Chen HS, Wey SP, Yen TC, Okamura N, Hsu JL. Biodistribution and radiation dosimetry for the tau tracer 18F-THK-5351 in healthy human subjects. J Nucl Med 2017 Mar 23. pii: jnumed.116.189126. doi: 10.2967/jnumed.116.189126. [Epub ahead of print] (SCI)

99.  Weng CC, Huang SL, Chen ZA, Lin KJ, Hsiao IT, Yen TC, Kung MP, *Wey SP, *Hsu CH. [18F]FP-(+)-DTBZ PET study in a lactacystin-treated rat model of Parkinson disease. Ann Nucl Med 2017 Apr 27. doi: 10.1007/s12149-017-1174-3. [Epub ahead of print] (SCI)

 

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