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Yew-Chuen Chang



Yew-Chuen Chang




Graduate Institute of Clinical Medical Sciences,

College of Medicine, Chang Gung University

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Research Interest :

  1. Molecular imaging diagnosis and prognosis analysis of gynecology oncology and esophageal cancer

  2. Nuclear medicine imaging diagnosis of pediatric kidney infection

  3. Molecular biology mechanism of cytokinesis

Instruction Courses :

  1.  Principles and Techniques of Nuclear Medicine

  2. Principles and Techniques of Nuclear Medicine Laboratory

  3. Practice of Nuclear Medicine Technology

Journal Papers:

(1)   Yu-Chen Chang, Tzu Chen Yen, Kai Yuan Tzen. Demonstration of Pleural Empyema on Ga-67 Planar and SPECT Imaging. Clin Nucl Med. 1999, 24(9): 707-709. (SCI)

(2)   Yu-Chen ChangKuo-Su Chen, Tzu-Chen Yen, Pan-Fu Kao, Ming-Fong Tsai, Kai-Yuan Tzen. Hydrothorax in Patients Receiving Continuous Ambulatory Peritoneal Dialysis Demonstrated by 99mTc-Sulfur Colloid. Ann Nucl Med Sci. 2000; 13: 81-85.

(3)   Shih-Ya Ma, Yu-Chen ChangKai-Yuan Tzen, Tzu-Chen Yen. Recurrent cervical lymph node metastases in a patient with parotid carcinoma after surgery and radiotherapy demonstrated on 18F-Flurodeoxyglucose positron emission tomography. Ann Nucl Med Sci. 2002; 15: 49-52.

(4)   Y.C. ChangP.F. Kao, M.S. Lee, M.C. Lin, K.Y. Tzen. Investigation of Pulmonary Epithelial Permeability after hyperbaric oxygen therapy by 99mTc diethylenetriaminepentaacetic acid aerosol inhalation lung scintigraphy. Nucl Med Commun. 2002; 23, 569-572. (SCI)

(5)   Yu-Chen Chang, Tzu-Chen Yen, Kai-Yuan Tzen. Detection of lung metastasis in a choriocarcinoma patient by FDG-PET scan. Ann Nucl Med Sci. 2002; 15: 103-105.

(6)   Yu-Chen Chang, Kai-Yuan Tzen, Chin-Song Lu, Tzu-Chen Yen, Wuu-Jyh Lin, Jenn-Tzong Chen. Vascular parkinsonism in FDG-PET scan: preliminary study. Ann Nucl Med Sci. 2002; 15: 113-117.

(7)   Ting-Chang Chang, Kim-Seng Law, Ji-Hong Hong, Chyong-Huey Lai, Koon-Kwan Ng, Suei Hsueh, Lai-Chu See, Yu-Chen Chang, Chien-Sheng Tsai, Hung-Hsueh Chou, Kuan-Gen Huang, Jui-Der Liou, Cheng-Tao Lin, Angel Chao, Min-Yu Chen, Tzu-I Wu, Shih-Ya Ma, Tzu-Chen Yen. Positron emission tomography for unexplained elevation of serum squamous cell carcinoma antigen levels during follow-up for patients with cervical malignancies. Cancer. 2004; 101:164-171. (SCI)

(8)   Sheng-Fong Kuo, Szu-Tah Chen, Pan-Fu Kao, Yu-Chen Chang, Shuo-Chi Chou, Jen-Der Lin. Papillary thyroid cancer with chest metastases only detected using radioactive iodine. Chang Gung Med J. 2004; 27:663-672.

(9)   Yen TC, See LC, Chang TC, Huang KG, Ng KK, Tang SG, Chang YC, Hsueh S, Tsai CS, Hong JH, Lin CT, Chao A, Ma SY, Lin WJ, Fu YK, Fan CC, Lai CH. Defining the priority of using 18F-FDG PET for recurrent cervical cancer. J Nucl Med. 2004; 45:1632-1639. (SCI)

(10)       Ng Shu-Hang, Joseph Chang Tung-Chieh, Chan Sheng-Chieh, Ko Sheung-Fat, Wang Hung-Ming, Liao Chun-Ta, Chang Yu-Chen, Wuu-Jyh Lin, Fu Ying-Kai, and Yen Tzu-Chen. Clinical Usefulness of 18F-FDG PET in Nasopharyngeal Carcinoma Patients with Questionable MRI Findings for Recurrence. J Nucl Med. 2004; 45: 1669-1676. (SCI)

(11)       Ng Shu-Hang, Joseph Chang Tung-Chieh, Chan Sheng-Chieh, Ko Sheung-Fat, Wang Hung-Ming, Liao Chun-Ta, Chang Yu-Chen, and Yen Tzu-Chen. Nodal metastases of nasopharyngeal carcinoma: patterns of disease on MRI and FDG PET. Eur J Nucl Med Mol Imaging. 2004; 31:1073-1080. (SCI=)

(12)       Yen TC, Chang JT, Ng SH, Chang YC, Chan SC, Lin KJ, Lin WJ, Fu YK, Lin CY. The value of 18F-FDG PET in the detection of stage M0 carcinoma of the nasopharynx. J Nucl Med. 2005; 46:405-410. (SCI)

(13)       Chang YC, Yen TC, Ng KK, See LC, Lai CH, Chang TC, Tsai CS, Hong JH, Hsueh S, Chou HH. Does diabetes mellitus influence the efficacy of FDG-PET in the diagnosis of cervical cancer? Eur J Nucl Med Mol Imaging. 2005; 32: 647-652. (SCI)

(14)       Shih-Yin Huang, Shih-Ming Jung, Koon-Kwan Ng, Yu-Chen Chang, Chyong-Huey Lai. Ovarian metastasis in a nulliparous woman with endometrial adenocarcinoma failing conservative hormone treatment. Gynecol Oncol. 2005; 97: 652-655. (SCI)

(15)       Tzu-Chen Yen, Yu-Chen Chang, Sheng-Chieh Chan, Joseph Tung-Chieh Chang, Ching-Han Hsu, Kun-Ju Lin, Wuu-Jyh Lin, Ying-Kai Fu, Shu-Hang Ng. Are dual-phase 18F-FDG PET scans necessary in nasopharyngeal carcinoma to assess the primary tumour and loco-regional nodes? Eur J Nucl Med Mol Imaging. 2005; 32:541–548. (SCI)

(16)       Yen TC, Chang JT, Ng SH, Chang YC, Chan SC, Wang HM, See LC, Chen TM, Kang CJ, Wu YF, Lin KJ, Liao CT. Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: comparison with head and neck CT/MRI and histopathology. J Nucl Med. 2005; 46:775-81. (SCI)

(17)       Chang JT, Chan SC, Yen TC, Liao CT, Lin CY, Lin KJ, Chen IH, Wang HM, Chang YC, Chen TM, Kang CJ, Ng SH. Nasopharyngeal carcinoma staging by 18F-Fluorodeoxyglucose positron emission tomography. Int J Radiat Oncol Biol Phys. 2005; 62:501-507. (SCI)

(18)       Chang TC, Yen TC, Li YT, Wu YC, Chang YC, Ng KK, Jung SM, Wu TI, Lai CH. The role of (18)F-fluorodeoxyglucose positron emission tomography in gestational trophoblastic tumours: a pilot study. Eur J Nucl Med Mol Imaging. 2006; 33:156–163. (SCI)

(19)       Chao AS. Chao A. Wang TH. Chang YC. Peng HH. Chang SD. Chao A. Chang CJ. Lai CH. Wong AM. Pain relief by applying transcutaneous electrical nerve stimulation (TENS) on acupuncture points during the first stage of labor: a randomized double-blind placebo-controlled trial. Pain. 2007; 127(3):214-220. (SCI)

(20)       Kuo SF, Chen JY, Chuang WY, Jung SM, Chang YC, Lin JD. Concurrent Papillary Thyroid Cancer with Pituitary ACTH-secreting Tumor. J Formos Med Assoc. 2007; 106(4): 330-335. (SCI)

(21)       Chao AS, Chao A, Wang TH, Chang YC, Chang YL, Hsieh CC, Lien R, Su WJ. Outcome of antenatally diagnosed cardiac rhabdomyoma: case series and a meta-analysis. Ultrasound Obstet Gynecol. 2008; 31(3):289-295. (SCI)

(22)       Kuo SF, Chao TC, Chang HY, Hsueh C, Chang YC, Yang CH, Lin JD. The role of radioactive iodine therapy in young patients with papillary thyroid cancer. Clin Nucl Med. 2009; 34(1):4-6. (SCI)

(23)       Lin CH, Ali R, Chen SC, Wallace C, Chang YC, Chen HC, Cheng MH. Vascularized Groin Lymph Node Transfer Using the Wrist as a Recipient Site for Management of Postmastectomy Upper Extremity Lymphedema. Plast. Reconstr Surg. 2009;123: 1265. (SCI)

(24)       Chang YC, Chen YJ, Wu CH, Wu YC, Yen TC, Ouyang P. Characterization of centrosomal proteins Cep55 and pericentrin in intercellular bridges of mouse testes. J Cell Biochem. 2010; 109:1274-1285. (SCI)

(25)       Cheng CHTsau YK, Chang CJ, Chang YC, Kuo CY, Tsai, IJ, Hsu YH, Lin TY. Acute lobar nephronia is associated with a high incidence of renal scarring in childhood urinary infections. Pediatr Infect Dis J. 2010; 29:624-628. (SCI)

(26)       Chang YC, Wu CH, Yen TC, Ouyang P. Centrosomal protein 55 (Cep55) stability is negatively regulated by p53 through polo-like kinase 1 (Plk1). J Biol Chem. 2012; 287:4376-4385. (SCI)

(27)       Hsieh MHFang YFChen GYChung FTLiu YCWu CHChang YCLin HC. The role of the high-sensitivity C-reactive protein in patients with stable non-cystic fibrosis bronchiectasis. Pulm Med. 2013;2013:795140. doi: 10.1155/2013/795140. Epub 2013 Dec 7. (SCI)

(28)       Pan TLHsu SYWang PWCheng YTChang YCSaha SHu JOuyang PFLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones. Cell Cycle. 2015 Apr 18;14(8):1174-87. doi: 10.1080/15384101.2015.1010906. (SCI)

(29)       Lin SYTsai CSChang YCNg KKChang TCKao WHLai CHHong JH. The Role of Pretreatment FDG-PET in Treating Cervical Cancer Patients With Enlarged Pelvic Lymph Node(s) Shown on MRI: A Phase 3 Randomized Trial With Long-Term Follow-Up. Int J Radiat Oncol Biol Phys. 2015 Jul 1;92(3):577-85. doi: 10.1016/j.ijrobp.2015.02.027. Epub 2015 Apr 28. (SCI)

(30)       Liu FY, Lai CH, Yang LY, Wang CC, Lin G, Chang CJ, Chang WY, Huang SH, Huang YE, Peng NJ, Hong JH, Chao A, Chou HH, Chang YC, Yen TC. Utility of 18F-FDG PET/CT in patients with advanced squamous cell carcinoma of the uterine cervix receiving concurrent chemoradiotherapy: a parallel study of a prospective randomized trial. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 2016; 43:1812-1823. (SCI)

(31)       Lin YM, Wu CC, Chang YC, Wu CH, Ho HL, Hu JW, Chang RC, Wang CT, Ouyang P. Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. Biochemical and Biophysical Research Communications 2016; 469: 903-910. (SCI)


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