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Kun-Ju Lin

　　　　　　　　　　　　 

　

　　

 
林昆儒

Title：

Professor

Education：

Ph.D., Institute of Clinical Medicine, Chang Gung University, Taiwan

Research Interest:

  1. Neural images (Affective disorder, Movement disorder and Alzheimer's disease)
  2. Molecular Images (autoradiography, animal PET/CT, animal SPECT/CT)
  3. New tracer development and translational studies (Serotonin, Dopamine, and VMAT2 images)

Association:

  1. Society of Nuclear Medicine (SNM), USA, Academy of Molecular Imaging (AMI), USA, The Taiwanese Society of Medical Cyclotron, Taiwan., Society of Nuclear Medicine, Taiwan.
  2. Committee member of The Taiwanese Society of Medical Cyclotron, Taiwan.
  3. Committee member of Institutional review board/ Radiation Protection Commitee / Institutional Animal Care and Use Committee Chang Gung Memorial Hospital, Taiwan.
  4. Editor, Scoiety of Nuclear Medicine Newsletter  / Chang Gung Medical Newsletters , Taiwan.

Instruction Courses:

  1. Nuclear Medicine Instrumentation
  2. Nuclear Medicine Technology

Lab Website:

http://cgu.cgmh-mi.com/

Journal Papers：

First author X9

1.          Lin KJ, Huang JY, Chen YS. Fully Automatic Region of Interest Selection in Glomerular Filtration Rate Estimation from 99mTc-DTPA Renogram. J Digit Imaging. 2011 Jan 28.

2.          Yao CH^, Lin KJ^, Weng CC, Hsiao IT, Ting YS, Yen TC, Jan TR, Daniel Skovronsky Kung MP, Wey SP*. GMP-compliant automated synthesis of [18F]AV-45 (Flobetapir F 18) for imaging beta-amyloid plaques in human brain. Appl Radiat Isot. 2010 Dec;68(12):2293-7. Epub 2010 Jul 7. (^Co-first author) (SCI)

3.          Lin KJ^, Weng YH^, Wey SP, Hsiao IT, Lu CS, Daniel Skovronsky, Chang HP, Kung MP*, Yen TC*. Whole-Body Biodistribution and Radiation Dosimetry of 18F-FP-(+)-DTBZ (18F-AV-133) – a Novel Vesicular Monoamine Transporter 2 Imaging Agent. J Nucl Med 2010; Sep;51(9):1480-5. Epub 2010 Aug 18. (SCI)

4.          Sonaje K^, Lin KJ^, Wey SP, Lin CK, Yeh TH, Nguyen HN, Hsu CW, Yen TC, Juang JH*, Sung HW*. Biodistribution, Pharmacodynamics and Pharmacokinetics of Insulin Analogues in a Rat Model: Oral Delivery Using pH-Responsive Nanoparticles vs. Subcutaneous Injection. Biomaterials 2010 Sep;31(26):6849-58. Epub 2010 Jun 17.(^Co-first author) (SCI)

5.          Tsao HH^, Lin KJ^, Juang JH, Daniel M. Skovronsky, Yen TC, Wey SP*, Kung MP*. Binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine (AV-133) to the vesicular monoamine transporter type 2 in rats. Nucl Med Biol. 2010 May;37(4):413-9. (^Co-first author) (SCI)

6.          Lin KJ^, Hsu WC^, Hsiao IT, Wey SP, Jin LW, Daniel Skovronsky, Wai YY, Chang HP, Lo CW, Yao CH, Yen TC*, Kung MP*. Whole-Body Biodistribution and Brain PET Imaging with 18F-AV-45, a Novel Amyloid Imaging Agent-a Pilot Study. Nucl Med Biol. 2010 May;37(4):497-508. (SCI)

7.          Hsiao IT^, Lin KJ^, Chang SI, Yen TC, Chen TC, Yeh TS*. Impaired liver regeneration of steatotic rats after portal vein ligation: particular emphasis on 99mTc-DISIDA scintigraphy and adiponectin signaling. J Hepatol. 2010 Apr;52(4):540-9. (SCI)

8.          Lin KJ, Liu HL, Hsu PH, Chung YH, Huang WC, Chen JC, Wey SP, Yen TC, Hsiao IT. Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat. Nuclear Medicine and Biology 2009 Oct;36(7):853-61. (SCI)

9.          Lin KJ, Liao CH, Hsiao IT, Yen TC, Chen TC, Jan YY, Chen MF, Yeh TS.  Improved hepatocyte function of future liver remnant of cirrhotic rats after portal vein ligation: a bonus other than volume shifting. Surgery 2009 Feb;145(2):202-11. (SCI)

Corresponding author X6

1.          Wang TC, Hsiao IT, Cheng YK, Wey SP, Yen TC, Lin KJ*. Noninvasive monitoring of tumor growth in a rat glioma model: comparison between neurological assessment and animal imaging. J Neurooncol. 2011 Feb 12.

2.          Nguyen HN, Wey SP, Juang JH, Sonaje K, Ho YC, Chuang EY, Hsu CW, Yen TC, Lin KJ*, Sung HW*. The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo. Biomaterials. 2011 Apr;32(10):2673-82. Epub 2011 Jan 21.

3.          Lin WY, Lin KJ, Weng YH, Yen TC, Shen LH, Liao MH, Lu CS, Preliminary studies of differential impairments of the dopaminergic system in subtypes of progressive supranuclear palsy. Nucl Med Commun. 2010;31:974-80. (SCI)

4.          Lin TJ, Huang CC, Wang IJ, Lin JW, Hung KS, Fan L, Tsao HH , Yang N, Lin KJ*.Validation of an animal FDG PET imaging system for study of human glioblastoma xenograft in mouse and rat glioma models. Ann Nucl Med Sci. 2010;23:77-83. (non SCI)

5.          Sonaje K, Chen YJ, Chen HL, Wey SP, Juang JH, Nguyen HN, Hsu CW, Lin KJ*, Sung HW*. Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials. (*Co-corresponding author) 2010 Apr;31(12):3384-94. (SCI)

6.          Yeh CN*, Lin KJ*, Hsiao IT, Yen TC, Chen TW, Jan YY, Chung YH, Lin CF,Chen MF, Animal PET for Thioacetamide induced Rat cholangiocarcinoma -A novel and reliable platform. Mol Imaging Biol 2008 Jul-Aug; 10(4): 209-216. (*equal contribution)

Coauthor X17

1.          Lu PL, Chen YC, Ou TW, Chen HH, Tsai HC, Wen CJ, Lo CL, Wey SP, Lin KJ, Yen TC, Hsiue GH. Multifunctional hollow nanoparticles based on graft-diblock copolymers for doxorubicin delivery. Biomaterials. 2011 Mar;32(8):2213-21.

2.          Huang BY, Lin JD, Chao TC, Lin KJ, Hseuh C, Tsang NM, Therapeutic Outcomes of Papillary Thyroid Cancer Patients in Different Risk Groups. Oncology. 2011 Jun 14;80(1-2):123-129.

3.          Huang BY, Hseuh C, Chao TC, Lin KJ, Lin JD, Well-Differentiated Thyroid Carcinoma with Concomitant Hashimoto’s Thyroiditis Present with Less Aggressive Clinical Stage and Low Recurrence. Endocrine Pathology

4.          Lin CY, Lin KJ, Kao CY, Chen MC, Lo WH, Yen TC, Chang YH, Hu YC. The Role of Adipose-derived Stem Cells Engineered with the Persistently Expressing Hybrid Baculovirus in the Healing of Massive Bone Defects. Biomaterials. 2011

5.          Sonaje K, Lin KJ, Wang JJ, Mi FL, Chen CT, Juang JH, Sung HW*. Self-Assembled pH-Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs. Advanced Functional Materials. (SCI 2010 Nov;21: 3695-3700. 引用：4)

6.          Lin JD, Lin KJ, Chao TC, Hseuh C, Tsang NM. Clinical Presentations of thyroid cancer patient with multiple primary cancers. J Endocrinological Investigation. (Accepted on 2010-08-04) 2011 May 24.

7.          Lin CY, Chang YH, Lin KJ, Yen TC, Tai CL, Chen CY, Lo WH, Hsiao IT, Hu YC*. The Healing of Critical-Sized Femoral Segmental Bone Defects in Rabbits Using Baculovirus-Engineered Mesenchymal Stem Cells. Biomaterials. 2010; 31:3222-3230. (SCI)

8.          Chuang CK, Lin KJ, Lin CY, Chang YH, Yen TC, Hwang SM, Sung LY, Chen HC, Hu YC*. Xenotransplantation of Human Mesenchymal Stem Cells into Immunocompetent Rats for Calvarial Bone Repair TISSUE ENGINEERING: Part A, 2010 Feb;16(2):479-88. (SCI)

9.          Tseng JH*, Ouyang CH, Lin KJ, Yeh TS*. Significance of Insulin Signaling in Liver Regeneration Triggered by Portal Vein Ligation. J Surg Res. 2009 Jul 30. (SCI)

10.      Lee PW, Hsu SH, Wang JJ, Tsai JS, Lin KJ, Wey SP, Chen FR, Lai CH, Yen TC*, Sung HW*. The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core-shell nanoparticles. Biomaterials. 2010; 31:1316-1324. (SCI)

11.      Lee JD*, Chu YH, Chen CW, Lin KJ. Multi-image registration for evaluating the 99mTc-TRODAT-1 of Parkinson's rat model. Conf Proc IEEE Eng Med Biol Soc. 2009;1:5801-4. (SCI)

12.      Chen MC, Wong HS, Lin KJ, Chen HL, Wey SP, Sonaje K, Lin YH, Chu CY, Sung HW*. The Characteristics, Biodistribution and Bioavailability of a Chitosan-based nanoparticulate System for the Oral Delivery of Heparin. Biomaterials, 2009; 30(34):6629-37. (SCI)

13.      Hsiao IT, Huang HM, Lin KJ, A fast OS-type Bayesian reconstruction with an edge-preserving median prior. J Inst JINST 4 P07012, 4 June 2009. (SCI)

14.      Wey SP, Weng CC, Lin KJ, Yao CH, Yen TC, Kung HF, Daniel Skovronsky, Kung MP. Validation of an 18F-labeled biphenylalkyne as a positron emission tomography imaging agent for β-amyloid plaques. Nuclear Medicine and Biology 2009, 36(4): 411-417.(SCI)

15.      Lin JD, Lin KJ, Chao TC, Hseuh C, Tsang NM. Therapeutic outcomes of papillary thyroid carcinomas with tumors more advanced than T1N0M0. Radiother Oncol 2008.

16.      Hsu JW, Hsu CH*, Hsiao IT, Lin KJ, Lin KM. A study of row-action reconstruction algorithm for small animal PET imaging using Inveon microPET. Ann Nucl Med Sci 2008 Sep; 21: 131-139. (non SCI)

17.      Cheng CW, Yang NI, Lin KJ, Hung MJ, Cherng WJ, Role of Coronary Spasm for a Positive Noninvasive Stress Test Result in Angina Pectoris Patients without Hemodynamically Significant Coronary Artery Disease. Am J Med Sci. 2008 May;335(5):354-62.(SCI)

 

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